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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital. |
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Data corrente: |
31/01/2018 |
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Data da última atualização: |
21/01/2020 |
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Tipo da produção científica: |
Resumo em Anais de Congresso |
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Autoria: |
CHUD, T. C. S.; BICKHART, D. M.; ZERLOTINI NETO, A.; COLE, J. B.; SILVA, M. V. G. B.; MUNARI, D. P. |
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Afiliação: |
TATIANE C. S. CHUD, FCAV/Unesp; DEREK M. BICKHART, FCAV/Unesp; ADHEMAR ZERLOTINI NETO, CNPTIA; JOHN B. COLE, Usda; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; DANÍSIO P. MUNARI, FCAV/Unesp. |
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Título: |
Copy number variation in dairy cattle using next-generation sequencing. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
In: PLANT AND ANIMAL GENOME CONFERENCE, 26., 2018, San Diego. Abstracts... [S.l.: s.n.], 2018. |
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Páginas: |
1 p. |
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Idioma: |
Inglês |
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Notas: |
PAG 2018. P0490. Na publicação: Adhemar Zerlotini, Marcos Vinicius B. da Silva. |
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Conteúdo: |
Gene copy number variants (CNV) have been shown to be associated with several production traits in dairy cattle; however, the detection and validation of CNVs in crossbred cattle is currently lacking. In order to provide a basis for future association studies, we sought to identify CNV regions (CNVRs) within the Girolando composite breed resulting from a mating of the Holstein (taurine) and Gir (indicine) breeds. A read depth method was performed using CNVnator software on NGS data from two Girolando, two Gir and ten Holstein bulls. The individual CNVs were merged into CNVRs based on genomic regions overlapping by at least 1 bp. In total, we identified a composite of 1,286 CNVRs (520 deletions, 255 duplications, 511 mixed) on the genomes of all samples. We observed 34 CNVRs (nine deletions, 25 mixed) in common (overlapping > 50%) only between Girolando and Holstein and 181 CNVRs (20 deletions, 21 duplications,140 mixed) only in Girolando and Gir, suggesting parent-of-origin inheritance from Holstein and Gir cattle, respectively. One of these Holstein-specific CNVRs intersected with the interleukin 6 family cytokine (LIF) gene which is linked to fat production and fertility traits in Holstein. Genes related to disease resistance (e.g. the CD4 gene) also coincided with CNVRs present only in Gir and Girolando cattle suggesting an indicine origin for the CNV. These results showed evidence of specific CNVRs shared by Girolando and purebred breeds which may be targeted for future selective breeding. MenosGene copy number variants (CNV) have been shown to be associated with several production traits in dairy cattle; however, the detection and validation of CNVs in crossbred cattle is currently lacking. In order to provide a basis for future association studies, we sought to identify CNV regions (CNVRs) within the Girolando composite breed resulting from a mating of the Holstein (taurine) and Gir (indicine) breeds. A read depth method was performed using CNVnator software on NGS data from two Girolando, two Gir and ten Holstein bulls. The individual CNVs were merged into CNVRs based on genomic regions overlapping by at least 1 bp. In total, we identified a composite of 1,286 CNVRs (520 deletions, 255 duplications, 511 mixed) on the genomes of all samples. We observed 34 CNVRs (nine deletions, 25 mixed) in common (overlapping > 50%) only between Girolando and Holstein and 181 CNVRs (20 deletions, 21 duplications,140 mixed) only in Girolando and Gir, suggesting parent-of-origin inheritance from Holstein and Gir cattle, respectively. One of these Holstein-specific CNVRs intersected with the interleukin 6 family cytokine (LIF) gene which is linked to fat production and fertility traits in Holstein. Genes related to disease resistance (e.g. the CD4 gene) also coincided with CNVRs present only in Gir and Girolando cattle suggesting an indicine origin for the CNV. These results showed evidence of specific CNVRs shared by Girolando and purebred breeds which may be targeted for future ... Mostrar Tudo |
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Palavras-Chave: |
Copy number variants. |
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Thesagro: |
Gado. |
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Thesaurus Nal: |
Cattle; Composite breeds. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/171991/1/PL-CopyNumber-PAGXXVI.pdf
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Marc: |
LEADER 02304nam a2200241 a 4500
001 2086860
005 2020-01-21
008 2018 bl uuuu u00u1 u #d
100 1 $aCHUD, T. C. S.
245 $aCopy number variation in dairy cattle using next-generation sequencing.$h[electronic resource]
260 $aIn: PLANT AND ANIMAL GENOME CONFERENCE, 26., 2018, San Diego. Abstracts... [S.l.: s.n.]$c2018
300 $a1 p.
500 $aPAG 2018. P0490. Na publicação: Adhemar Zerlotini, Marcos Vinicius B. da Silva.
520 $aGene copy number variants (CNV) have been shown to be associated with several production traits in dairy cattle; however, the detection and validation of CNVs in crossbred cattle is currently lacking. In order to provide a basis for future association studies, we sought to identify CNV regions (CNVRs) within the Girolando composite breed resulting from a mating of the Holstein (taurine) and Gir (indicine) breeds. A read depth method was performed using CNVnator software on NGS data from two Girolando, two Gir and ten Holstein bulls. The individual CNVs were merged into CNVRs based on genomic regions overlapping by at least 1 bp. In total, we identified a composite of 1,286 CNVRs (520 deletions, 255 duplications, 511 mixed) on the genomes of all samples. We observed 34 CNVRs (nine deletions, 25 mixed) in common (overlapping > 50%) only between Girolando and Holstein and 181 CNVRs (20 deletions, 21 duplications,140 mixed) only in Girolando and Gir, suggesting parent-of-origin inheritance from Holstein and Gir cattle, respectively. One of these Holstein-specific CNVRs intersected with the interleukin 6 family cytokine (LIF) gene which is linked to fat production and fertility traits in Holstein. Genes related to disease resistance (e.g. the CD4 gene) also coincided with CNVRs present only in Gir and Girolando cattle suggesting an indicine origin for the CNV. These results showed evidence of specific CNVRs shared by Girolando and purebred breeds which may be targeted for future selective breeding.
650 $aCattle
650 $aComposite breeds
650 $aGado
653 $aCopy number variants
700 1 $aBICKHART, D. M.
700 1 $aZERLOTINI NETO, A.
700 1 $aCOLE, J. B.
700 1 $aSILVA, M. V. G. B.
700 1 $aMUNARI, D. P.
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Registro original: |
Embrapa Agricultura Digital (CNPTIA) |
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Biblioteca |
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| Registros recuperados : 49 | |
| 1. |  | AGUIAR, M. I. de; MAIA, S. M. F.; XAVIER, F. A. da S.; MENDONÇA, E. de S.; ARAUJO FILHO, J. A. de; OLIVEIRA, T. S. de. Sediment, nutrient and water losses by water erosion under agroforestry systems in the semi-arid region in northeastern Brazil. Agroforest System, v. 79, n. 3, p. 277-289, Jul. 2010.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 2. | | ASSIS, C. P. de; JUCKSCH, I.; MENDONÇA, E. de S.; NEVES, J. C. L. Carbono e nitrogênio em agregados de Latossolo submetido a diferentes sistemas de uso e manejo. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 41, n. 10, p. 1541-1550, out. 2006 Título em inglês: Carbon and nitrogen in aggregates of an Oxisol submitted to different use and management systems.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 5. | | BENITES, V. de M.; MENDONCA, E. de S.; SCHAEFER, C. E. G. R.; NOVOTNY, E. H.; REIS, E. L.; KER, J. C. Properties of black soil humic acids from high altitude rocky complexes in Brazil. Geoderma, Amsterdam, v. 127, n. 1/2, p. 104-113, 2005.| Tipo: Artigo em Periódico Indexado |
| Biblioteca(s): Embrapa Milho e Sorgo; Embrapa Solos. |
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| 6. | | BIGHI, K. N.; PAULA, R. R.; CALDEIRA, M. V. W.; BURAK, D. L.; MENDONÇA, E. de S.; SOUZA, P. H. de; DELARMELINA, W. M.; BALIEIRO, F. de C. Nitrogen pools in tropical plantations of N2-fixing and non-N2-fixing legume trees under different tree stand densities. Nitrogen, v. 2, n. 1, p. 86-98, 2021.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 5 |
| Biblioteca(s): Embrapa Solos. |
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| 8. | | GOMES, J. B. V.; RESENDE, M.; REZENDE, S. B. de; MENDONÇA, E. de S. Águas freáticas de três áreas de restinga e suas relações com os processos de formação dos solos. In: CONGRESSO LATINO AMERICANO DE CIÊNCIA DO SOLO, 13.; REUNIÃO BRASILEIRA DE BIOLOGIA DO SOLO, 1.; SIMPÓSIO BRASILEIRO SOBRE MICROBIOLOGIA DO SOLO, 4.; REUNIÃO BRASILEIRA SOBRE MICORRIZAS, 6.; REUNIÃO BRASILEIRA DE MANEJO E CONSERVAÇÃO DO SOLO E DA ÁGUA, 11., 1996, Águas de Lindóia. Solo suelo 96. Campinas: Sociedade Brasileira de Ciência do Solo, 1996. 1 CD-ROM.| Biblioteca(s): Embrapa Solos. |
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| 9. | | GOMES, J. B. V.; RESENDE, M.; REZENDE, S. B. de; MENDONCA, E. de S. Solos de três áreas de restinga. II. Dinâmica de substancias húmicas, ferro e alumínio. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 33, n. 11, p. 1921-1932, nov. 1998. Título em inglês: Soil profiles from three coastal plain regions. II. Dynamics of humic substances, iron and aluminum.| Tipo: Artigo em Periódico Indexado |
| Biblioteca(s): Embrapa Solos; Embrapa Unidades Centrais. |
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| 10. | | GOMES, J. B. V.; RESENDE, M.; REZENDE, S. B. de; MENDONÇA, E. de S. Solos de três áreas de restinga. I. Morfologia, caracterização e classificação. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 33, n. 11, p. 1907-19, nov. 1998. Título em inglês: Soil profiles from three coastal plain regions. I. Morphology, characterization and classification.| Tipo: Artigo em Periódico Indexado |
| Biblioteca(s): Embrapa Solos; Embrapa Unidades Centrais. |
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| 11. | | GOMES, P. C.; FONTES, M. P. F.; COSTA, L. M. da; MENDONCA, E. de S. Fracionamento de Cd, Cr, Cu, Ni e Pb influenciado por doses de metais em latossolo vermelho-amarelo. In: CONGRESSO BRASILEIRO DE CIENCIA DO SOLO, 26., 1997. Rio de Janeiro, RJ. Resumos... Rio de Janeiro: Sociedade Brasileira de Ciencia do Solo, 1997. p.480.| Biblioteca(s): Embrapa Solos. |
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| 20. | | LISBÔA, F. M.; DONAGEMMA, G. K.; BURAK, D. L.; PASSOS, R. R.; MENDONÇA, E. de S. Indicadores de qualidade de Latossolo relacionados à degradação de pastagens. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 51, n. 9, p. 1184-1193, set. 2016.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Solos; Embrapa Unidades Centrais. |
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| Registros recuperados : 49 | |
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